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KMID : 0603519990040040196
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Journal of Korean Association of Cancer Prevention
1999 Volume.4 No. 4 p.196 ~ p.203
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Antioxidative Mechanism of Indole Derivatives
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Soung Do-Yu
Park Jin-Seug
Kim Myung-Jung
No Jae-Kyung
Yang Young-Hwan
Paik Kee-Joo
Yang Ryung
Choi Jin-Ho
Lee Sook-Hee
Chung Hae-Young
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Abstract
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Reactive oxygen species (ROS) mediate reactions which can damage a variety of critical biological molecules including DNA, proteins, and lipids. The present study was carried out to investigate the scavenging activities of indole derivatives against ROS and their scavenging mechanisms. Thus, eight indole derivatives were screened for the scavenging effects against O2-, H2O2, -OH, and ROS. Among them, indole derivatives with a hydroxyl group at the position 5 showed the strongest scavenging activitiy. 5-Hydroxyl indole derivatives significantly protected cultured PC12 and CPAE from damage induced by t-butylhydroperoxide (BHP). Especially, serotonin and N-acetyl 5-hydroxytryptamine showed the strongest cytoprotection. In vivo experiment, serotonin and N-acetyl 5-hydroxytryptamine reduced lipid peroxidation in ICR mice given BHP. In these experiments, serotonin and N-acetyl 5-hydroxytryptamine markedly showed the protective effect against ROS-induced stress in vivo and in vitro experiments.
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KEYWORD
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Indole derivatives, Reactive oxygen species, Scavenging
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